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Article

Herpes Vector–mediated Gene Transfer in the Treatment of Chronic Pain

7 Oct 2008

Abstract excerpt

Chronic pain is a major health concern with up to 50% of patients finding little if any relief following traditional pharmacotherapy. This review describes the treatment of chronic pain using herpes simplex virus type 1 (HSV)-based vectors. HSV can be effectively used to deliver pain-modulating transgenes to sensory neurons in vivo following intradermal inoculation. The vector genome persists in peripheral nerve...

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Share to Hereditary Neurological Disorders
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Identifiers

PMID: 18841093
DOI: 10.1038/mt.2008.213

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