Article

Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice

2020-02-09

Abstract excerpt

<h4>Objective</h4> Joint pain is the major clinical symptom of arthritis that affects millions of people. Controlling the excitability of knee-innervating dorsal root ganglion (DRG) neurons (knee neurons) could potentially provide pain relief. Therefore, our objective was to evaluate whether the newly engineered adeno-associated virus (AAV) serotype, AAV-PHP.S, can deliver functional artificial receptors to contr...

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Literature Corpus work: 1e28445c-7ec7-5eb4-8d1c-a6f0e94fe6e0
DOI: 10.1101/2020.02.08.939066

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