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Article

Efficient delivery of RNA Interference to peripheral neurons in vivo using herpes simplex virus

27 Jun 2008

Abstract excerpt

Considerable interest has been focused on inducing RNA interference (RNAi) in neurons to study gene function and identify new targets for disease intervention. Although small interfering RNAs (siRNAs) have been used to silence genes in neurons, in vivo delivery of RNAi remains a major challenge limiting its applications. We have developed a highly efficient method for in vivo gene silencing in dorsal root ganglia...

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PMID: 18583367
DOI: 10.1093/nar/gkn371

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