Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates

Abstract excerpt

14-3-3 proteins regulate cellular responses to stimuli by docking onto pairs of phosphorylated residues on target proteins. The present study shows that the human 14-3-3-binding phosphoproteome is highly enriched in 2R-ohnologues, which are proteins in families of two to four members that were generated by two rounds of whole genome duplication at the origin of the vertebrates. We identify 2R-ohnologue families...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 14-3-3 protein interactions
• Share to Microbial Natural Products and Biosynthesis
• Share to Ubiquitin and proteasome pathways