Article
In vivo functional specificity and homeostasis of Drosophila 14-3-3 proteins.
Genetics - 1 Sept 2007
Acevedo Summer F, Tsigkari K Kirki, Grammenoudi Sofia, Skoulakis Efthimios M C
Abstract excerpt
The functional specialization or redundancy of the ubiquitous 14-3-3 proteins constitutes a fundamental question in their biology and stems from their highly conserved structure and multiplicity of coexpressed isotypes. We address this question in vivo using mutations in the two Drosophila 14-3-3 genes, leonardo (14-3-3zeta) and D14-3-3epsilon. We demonstrate that D14-3-3epsilon is essential for embryonic...
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