Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants.

Abstract excerpt

14-3-3 is now accepted as a novel type of dimeric protein that can modulate interaction between proteins involved in cell signalling and other functions. Target proteins that interact with 14-3-3 isoforms are involved in regulation of cell cycle, intracellular trafficking/targeting, signal transduction, cytoskeletal structure and transcription. In many cases, these proteins show a distinct preference for a...

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