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Article

Alternative cell death of Apaf1-deficient neural progenitor cells induced by withdrawal of EGF or insulin.

Biochimica et biophysica acta - 1 Mar 2010

Shiraishi Hiroshi, Okamoto Hideaki, Hara Hiromitsu, Yoshida Hiroki

Abstract excerpt

BACKGROUND: Various forms of cell death, such as apoptotic, autophagic and non-lysosomal types, are implicated in normal physiological processes. Apoptotic protease activating factor 1 (Apaf1) is an important component of the intrinsic apoptotic pathway. Deficiency of Apaf1 results in an accumulation of neural progenitor cells (NPCs) in the developing central nervous system and thus, in perinatal lethality. A...

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Identifiers

PMID: 19914347
DOI: 10.1016/j.bbagen.2009.11.008

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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