Article
Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis.
Gut - 1 Jul 2011
Pinho Andreia V, Rooman Ilse, Reichert Maximilian, De Medts Nele, Bouwens Luc, Rustgi Anil K, Real Francisco X
Abstract excerpt
OBJECTIVE: Acinar cells display plasticity in vitro and in vivo and can activate a variety of differentiation programmes that may contribute to pancreatic diseases. The aims were to determine: (1) the differentiation potential of acinar cells under conditions which favour stem cell survival, and (2) its relationship to the phenotypes acquired by pancreatic epithelial cells in chronic pancreatitis. DESIGN: Murine...
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