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Article

ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy.

Mechanisms of ageing and development - 1 Sept 2020

Sunderland Piotr, Augustyniak Justyna, Lenart Jacek, Bużańska Leonora, Carlessi Luigi, Delia Domenico, Sikora Ewa

Abstract excerpt

ATM is a kinase involved in DNA damage response (DDR), regulation of response to oxidative stress, autophagy and mitophagy. Mutations in the ATM gene in humans result in ataxi A-Telangiectasia disease (A-T) characterized by a variety of symptoms with neurodegeneration and premature ageing among them. Since brain is one of the most affected organs in A-T, we have focused on senescence of neural progenitor cells...

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PMID: 32621937
DOI: 10.1016/j.mad.2020.111296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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