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Article

Synaptotagmin controls and modulates synaptic-vesicle fusion in a Ca(2+)-dependent manner.

Trends in neurosciences - 1 Apr 1995

Littleton J T, Bellen H J

Abstract excerpt

Although numerous electrophysiological and biochemical studies have defined many of the properties of the putative Ca2+ receptor for exocytosis at the synapse, the molecular mechanisms that couple influx of Ca2+ and release of neurotransmitter have remained elusive. Several proteins have emerged recently as putative Ca2+ sensors. Interestingly, one of these proteins, synaptotagmin, shares many properties with the...

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Identifiers

PMID: 7778189
DOI: 10.1016/0166-2236(95)93898-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Synaptotagmin controls and modulates synaptic-vesicle fusion in a Ca(2+)-dependent manner.PMID 7778189Read ↗

How does synaptotagmin trigger neurotransmitter release?Semantic proximity Read ↗

The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.Semantic proximity Read ↗

Genetic and molecular analysis of the synaptotagmin family.Semantic proximity Read ↗

Synaptotagmin-Ca2+ triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation.Semantic proximity Read ↗

Neural transmission. Synaptotagmin is just a calcium sensor.Semantic proximity Read ↗

Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans.Semantic proximity Read ↗

synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo.Semantic proximity Read ↗

Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.Semantic proximity Read ↗

Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.Semantic proximity Read ↗

Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Semantic proximity Read ↗

Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.Semantic proximity Read ↗

The C2 domains of synaptotagmin--partners in exocytosis.Semantic proximity Read ↗

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