Article
Effect of the TaqIA polymorphism on ethanol response in the brain.
Psychiatry research - 30 Dec 2009
London Edythe D, Berman Steven M, Mohammadian Parvenah, Ritchie Terrie, Mandelkern Mark A, Susselman Mary K W, Schlagenhauf Florian, Noble Ernest P
Abstract excerpt
Acute ethanol administration increases striatal dopamine release and decreases cerebral glucose metabolism. The A1 allele of the ANKK1 TaqIa polymorphism is associated with lower dopaminergic tone and greater risk for alcoholism, but the mechanisms are unclear. We hypothesized that ethanol would...
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