GABRB1 Single Nucleotide Polymorphism Associated with Altered Brain Responses (but not Performance) during Measures of Impulsivity and Reward Sensitivity in Human Adolescents

Abstract excerpt

Variations in genes encoding several GABAA receptors have been associated with human drug and alcohol abuse. Among these, a number of human studies have suggested an association between GABRB1, the gene encoding GABAA receptor 1 subunits, with alcohol dependence, both on its own and comorbid with other substance dependence and psychiatric illnesses. In the present study, we hypothesised that the GABRB1...

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