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Article

Influence of CTLA-4/CD28/ICOS gene polymorphisms on the susceptibility to cervical squamous cell carcinoma and stage of differentiation in the Polish population.

Human immunology - 1 Feb 2010

Pawlak Edyta, Karabon Lidia, Wlodarska-Polinska Iwona, Jedynak Anna, Jonkisz Anna, Tomkiewicz Anna, Kornafel Jan, Stepien Marcin, Ignatowicz Agnieszka, Lebioda Arleta, Dobosz Tadeusz, Frydecka Irena

Abstract excerpt

Abnormal expressions of the costimulatory molecules CD28, "inducible co-stimulator" (ICOS), and inhibitory molecule cytotoxic T-lymphocyte antigen-4 (CTLA-4) lead to disturbances of immune response and entail an increased risk of cancer. This study was undertaken to evaluate the association between the polymorphisms CTLA-4c.49A>G, CTLA-4g.319C>T, CTLA-4g.*642AT(8_33), CTLA-4g.*6230G>A (CT60), CD28c.17+3T>C, and...

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Share to Antigens, CD
Share to Antigens, Differentiation, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to CD28 Antigens

Share to CTLA-4 Antigen

Share to Inducible T-Cell Co-Stimulator Protein

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Share to Uterine Cervical Neoplasms

Source

Identifiers

PMID: 19913589
DOI: 10.1016/j.humimm.2009.11.006

Genes

ICOS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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