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Article

New approach reveals CD28 and IFNG gene interaction in the susceptibility to cervical cancer.

Human molecular genetics - 15 Jun 2008

Guzman Valeska B, Yambartsev Anatoly, Goncalves-Primo Amador, Silva Ismael D C G, Carvalho Carmen R N, Ribalta Julisa C L, Goulart Luiz Ricardo, Shulzhenko Natalia, Gerbase-Delima Maria, Morgun Andrey

Abstract excerpt

Cervical cancer is a complex disease with multiple environmental and genetic determinants. In this study, we sought an association between polymorphisms in immune response genes and cervical cancer using both single-locus and multi-locus analysis approaches. A total of 14 single nucleotide polymorphisms (SNPs) distributed in CD28, CTLA4, ICOS, PDCD1, FAS, TNFA, IL6, IFNG, TGFB1 and IL10 genes were determined in...

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Source

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Identifiers

PMID: 18337305
DOI: 10.1093/hmg/ddn077
PMCID: PMC2536747

Genes

IFNG
ICOS
PDCD1
CTLA4
FAS
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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