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Article

Is the Genetic Background of Co-Stimulatory CD28/CTLA-4 Pathway the Risk Factor for Prostate Cancer?

Pathology oncology research : POR - 1 Oct 2017

Karabon Lidia, Tupikowski K, Tomkiewicz A, Partyka A, Pawlak-Adamska E, Wojciechowski A, Kolodziej A, Dembowski J, Zdrojowy R, Frydecka I

Abstract excerpt

The impairment of immunological surveillance caused by aberrant T cell activation can lead to an inadequate anti-tumor response. Therefore, deregulation in co-stimulatory pathway might be associated with cancer susceptibility. Here we undertook a prospective study to investigate whether genetic variations in gene encoding molecule CD28 and CTLA-4 playing pivotal role in regulating adoptive immune response can...

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PMID: 28101800
DOI: 10.1007/s12253-016-0180-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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