Article
HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia.
Arthritis research & therapy - 1 Jan 2009
Paladini Fabiana, Belfiore Francesca, Cocco Elisa, Carcassi Carlo, Cauli Alberto, Vacca Alessandra, Fiorillo Maria Teresa, Mathieu Alessandro, Cascino Isabella, Sorrentino Rosa
Abstract excerpt
INTRODUCTION: Ankylosing spondylitis (AS) is a severe, chronic inflammatory disease strongly associated with HLA-B27. The presence of additional HLA risk factors has been suggested by several studies. The aim of the current study is to assess the occurrence of an additional HLA susceptibility locus in the region between HLA-E and HLA-C in the Sardinian population. METHODS: 200 random controls, 120 patients with...
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