Article
Two distinctive HLA haplotypes harbor the B27 alleles negatively or positively associated with ankylosing spondylitis in Sardinia: implications for disease pathogenesis.
Arthritis and rheumatism - 1 May 2003
Fiorillo Maria Teresa, Cauli Alberto, Carcassi Carlo, Bitti Pier Paolo, Vacca Alessandra, Passiu Giuseppe, Bettosini Francesca, Mathieu Alessandro, Sorrentino Rosa
Abstract excerpt
OBJECTIVE: To compare haplotype distribution in HLA-B27-positive patients with ankylosing spondylitis (AS) and healthy control subjects possessing either AS-associated HLA-B27 alleles or the non-AS-associated HLA-B*2709 allele. METHODS: DNA samples from 47 HLA-B27-positive patients with AS and 76 HLA-B27-positive healthy controls (19 positive and 57 negative for B*2709) living in different areas of Sardinia were...
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