Article
Identification of previously unrecognized predisposing factors for ankylosing spondylitis from analysis of HLA-B27 extended haplotypes in Sardinia.
Arthritis and rheumatism - 1 Aug 2007
Cascino Isabella, Paladini Fabiana, Belfiore Francesca, Cauli Alberto, Angelini Claudia, Fiorillo Maria Teresa, Mathieu Alessandro, Sorrentino Rosa
Abstract excerpt
OBJECTIVE: To define the contribution of HLA genes other than HLA-B27 in conferring susceptibility to ankylosing spondylitis (AS), through analysis of HLA-B27 haplotypes in Sardinian subjects. METHODS: Ninety-eight patients with AS, 133 HLA-B27-positive controls (of whom 33 were positive for HLA-B*2709), and 190 randomly selected controls were genotyped for microsatellites and single-nucleotide polymorphisms...
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