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Article

CD28 and CTLA4 polymorphisms associated with ankylosing spondylitis: a study in the context of HLA-B27.

BMC immunology - 19 May 2025

Yu Kuang-Hui, Wu Gem Huai-Chueh, Yang Chia-Ju, Lin Wei-Tzu, Hsu Fang-Ping, Chen Ding-Ping

Abstract excerpt

BACKGROUND: The human leukocyte antigen (HLA)-B27 gene is highly associated with ankylosing spondylitis (AS). However, not everyone who carries the HLA-B27 antigen develops AS, indicating that factors beyond the HLA-B27 gene contribute to the disease's onset. AS is an autoimmune disease in which co-stimulatory systems have been widely explored. Therefore, we aimed to analyze the association between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40389847
DOI: 10.1186/s12865-025-00720-9
PMCID: PMC12087045

Genes

CD28
CTLA4
PDCD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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