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Article

Fission yeast CENP-B homologs nucleate centromeric heterochromatin by promoting heterochromatin-specific histone tail modifications.

Genes & development - 15 Jul 2002

Nakagawa Hiromi, Lee Joon-Kyu, Hurwitz Jerard, Allshire Robin C, Nakayama Jun-Ichi, Grewal Shiv I S, Tanaka Katsunori, Murakami Yota

Abstract excerpt

Heterochromatin is a functionally important chromosomal component, especially at centromeres. In fission yeast, conserved heterochromatin-specific modifications of the histone H3 tail, involving deacetylation of Lys 9 and Lys 14 and subsequent methylation of Lys 9, promote the recruitment of a heterochromatin protein, Swi6, a homolog of the Drosophila heterochromatin protein 1. However, the primary determinants...

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Identifiers

PMID: 12130537
DOI: 10.1101/gad.997702
PMCID: PMC186399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fission yeast CENP-B homologs nucleate centromeric heterochromatin by promoting heterochromatin-specific histone tail modifications.PMID 12130537Read ↗

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The chromodomain protein Swi6: a key component at fission yeast centromeres.Semantic proximity Read ↗

Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation.Semantic proximity Read ↗

Centromere silencing and function in fission yeast is governed by the amino terminus of histone H3.Semantic proximity Read ↗

A DNA polymerase alpha accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast.Semantic proximity Read ↗

CENP-H-containing complex facilitates centromere deposition of CENP-A in cooperation with FACT and CHD1.Semantic proximity Read ↗

A new role for the transcriptional corepressor SIN3; regulation of centromeres.Semantic proximity Read ↗

Interaction of APC/C-E3 ligase with Swi6/HP1 and Clr4/Suv39 in heterochromatin assembly in fission yeast.Semantic proximity Read ↗

The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A.Semantic proximity Read ↗

Sfh1, an essential component of the RSC chromatin remodeling complex, maintains genome integrity in fission yeast.Semantic proximity Read ↗

A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres.Semantic proximity Read ↗

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