Article
Recombinant measles viruses with mutations in the C, V, or F gene have altered growth phenotypes in vivo.
Journal of virology - 1 Oct 1998
Valsamakis A, Schneider H, Auwaerter P G, Kaneshima H, Billeter M A, Griffin D E
Abstract excerpt
An understanding of the determinants of measles virus (MV) virulence has been hampered by the lack of an experimental model of infection. We have previously demonstrated that virulence phenotypes in human infections are faithfully reproduced by infection of human thymus/liver (thy/liv) implants engrafted into SCID mice, where the virus grows primarily in stromal cells but induces thymocyte apoptosis (P. G....
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