Recombinant measles viruses with mutations in the C, V, or F gene have altered growth phenotypes in vivo.

doi:10.1128/JVI.72.10.7754-7761.1998

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Article

Recombinant measles viruses with mutations in the C, V, or F gene have altered growth phenotypes in vivo.

Journal of virology - 1 Oct 1998

Valsamakis A, Schneider H, Auwaerter P G, Kaneshima H, Billeter M A, Griffin D E

Abstract excerpt

An understanding of the determinants of measles virus (MV) virulence has been hampered by the lack of an experimental model of infection. We have previously demonstrated that virulence phenotypes in human infections are faithfully reproduced by infection of human thymus/liver (thy/liv) implants e...

Topics

Animals
Base Sequence
DNA Primers
Humans
Liver
Male
Measles virus
Mice
Mice, SCID
Mutation
Phenotype
Recombination, Genetic
Thymus Gland
Viral Proteins
Virus Replication

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