Article
Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene
9 May 2000
Abstract excerpt
To produce disease, viruses must enter the host, multiply locally in host tissues, spread from the site of entry, and overcome or evade host immune responses. At each stage in this infectious process, specific microbial and host genes determine the ultimate virulence of the virus. Genetic approaches have identified many viral genes that play critical roles in virulence and are presumed to target specific...
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