Pathogenicity of a thymidine kinase-deficient mutant of equine herpesvirus 1 in mice and specific pathogen-free foals.

doi:10.1099/0022-1317-74-5-819

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Article

Pathogenicity of a thymidine kinase-deficient mutant of equine herpesvirus 1 in mice and specific pathogen-free foals.

The Journal of general virology - 1 May 1993

Slater J D, Gibson J S, Field H J

Abstract excerpt

Both intranasal (i.n.) and intracerebral (i.c.) inoculation of mice with wild-type equine herpesvirus type 1 (wt EHV-1) caused clinical signs and mortality. Virus could be recovered from target organs (turbinates, lungs and blood) for several days. By contrast, the thymidine kinase (TK)-deficient...

Topics

Animals
Animals, Newborn
Cell Line
Cerebral Cortex
Female
Herpesviridae Infections
Herpesvirus 1, Equid
Horses
Mice
Mice, Inbred BALB C
Mutation
Nasal Mucosa
Rabbits
Specific Pathogen-Free Organisms
Thymidine Kinase

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