Article
Deletion of the Herpes simplex 1 internal repeat sequences affects pathogenicity in the mouse.
Frontiers in bioscience : a journal and virtual library - 4 Oct 1996
Jenkins F J, Donoghue A M, Martin J R
Abstract excerpt
We have isolated three different herpes simplex virus 1 (HSV-1) recombinant viruses, each frozen in either the P (prototype), IS (inversion of S component), or ILS (inversion of both components) genome arrangement. Common to all three recombinant viruses is the deletion of approximately 14 kilobases (kb) of viral DNA sequences representing greater than 95% of the internal repeat sequences and the insertion of a...
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