Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of wingless-type MMTV integration site family (WNT) signalling in pancreatic islets from wild-type and obese mice.

Diabetologia - 1 Jan 2010

Krützfeldt J, Stoffel M

Abstract excerpt

AIMS/HYPOTHESIS: TCF7L2 is a type 2 diabetes susceptibility gene and downstream effector of canonical wingless-type MMTV integration site family (WNT) signalling. However, it is unknown whether this pathway is active in adult pancreatic islets in vivo, and whether it is regulated in obesity. METHODS: We analysed activation of endogenous WNT signalling in the endocrine pancreas from wild-type and obese mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hyperinsulinism
Share to Islets of Langerhans
Share to Mammary Tumor Virus, Mouse

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Obese

Share to TCF Transcription Factors

Share to Transcription Factor 7-Like 2 Protein

Share to Virus Integration

Share to Wnt Proteins

Source

Identifiers

PMID: 19898815
DOI: 10.1007/s00125-009-1578-2

Genes

WNT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of wingless-type MMTV integration site family (WNT) signalling in pancreatic islets from wild-type and obese mice.PMID 19898815Read ↗

Wnt signaling in pancreatic islets.Semantic proximity Read ↗

Islet Specific Wnt Activation in Human Type II DiabetesSemantic proximity Read ↗

The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspectiveSemantic proximity Read ↗

Pancreatic Pericytes Support β-Cell Function in a Tcf7l2-Dependent Manner.Semantic proximity Read ↗

Wnt signaling regulates pancreatic β cell proliferationSemantic proximity Read ↗

Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function.Semantic proximity Read ↗

Wnt-signalling and the Metabolic SyndromeSemantic proximity Read ↗

TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals.Semantic proximity Read ↗

Pathophysiological aspects of Wnt-signaling in endocrine diseaseSemantic proximity Read ↗

Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolismSemantic proximity Read ↗

The WNT signalling pathway and diabetes mellitusSemantic proximity Read ↗

The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell MaturationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.