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Article

Islet Specific Wnt Activation in Human Type II Diabetes

1 Jan 2008

Abstract excerpt

The Wnt pathway effector gene TCF7L2 has been linked to type II diabetes, making it important to study the role of Wnt signaling in diabetes pathogenesis. We examined the expression of multiple Wnt pathway components in pancreases from normal individuals and type II diabetic individuals. Multiple members of the Wnt signaling pathway, including TCF7L2, Wnt2b, beta-catenin, pGSK3beta, TCF3, cyclinD1, and c-myc,...

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Identifiers

PMID: 19165345
DOI: 10.1155/2008/728763

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