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Article

Pathophysiological aspects of Wnt-signaling in endocrine disease

27 Feb 2009

Abstract excerpt

Wnt-signaling has recently been identified as a regulator of a number of endocrine functions in health and disease in addition to its original attribution to developmental biology. Wnts are extracellular ligands on frizzled receptors and on lipoprotein receptor-related protein co-receptors. Ligand binding leads eventually to the activation of intracellular signaling cascades; based on the involvement of the...

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PMID: 19246555
DOI: 10.1530/eje-08-0831

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