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The WNT signalling pathway and diabetes mellitus

11 Aug 2008

Abstract excerpt

The WNT signalling pathway is involved in many physiological and pathophysiological activities. WNT ligands bind to Frizzled receptors and co-receptors (LDL receptor-related protein 5/6), triggering a cascade of signalling events. The major effector of the canonical WNT signalling pathway is the bipartite transcription factor beta-catenin/T cell transcription factor (beta-cat/TCF), formed by free beta-cat and one...

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PMID: 18696049
DOI: 10.1007/s00125-008-1084-y

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