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Article

The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation

8 May 2019

Abstract excerpt

Current published protocols for targeted differentiation of human stem cells towards pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to assess whether Wnt-modulation could promote the final protocol stages of β-cell maturation, building our hypothesis on our previous findings of Wnt activation in immature hiPSC-derived S7 cells...

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Share to Genetics and Neurodevelopmental Disorders
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Share to Wnt/β-catenin signaling in development and cancer

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Identifiers

PMID: 31139151
DOI: 10.3389/fendo.2019.00293

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