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Article

Escherichia coli cells with increased levels of DnaA and deficient in recombinational repair have decreased viability.

Journal of bacteriology - 1 Jan 2003

Grigorian Aline V, Lustig Rachel B, Guzmán Elena C, Mahaffy Joseph M, Zyskind Judith W

Abstract excerpt

The dnaA operon of Escherichia coli contains the genes dnaA, dnaN, and recF encoding DnaA, beta clamp of DNA polymerase III holoenzyme, and RecF. When the DnaA concentration is raised, an increase in the number of DNA replication initiation events but a reduction in replication fork velocity occurs. Because DnaA is autoregulated, these results might be due to the inhibition of dnaN and recF expression. To test...

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Identifiers

PMID: 12511510
DOI: 10.1128/JB.185.2.630-644.2003
PMCID: PMC145335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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