Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective ribonucleoside diphosphate reductase impairs replication fork progression in Escherichia coli.

Journal of bacteriology - 1 May 2007

Guarino Estrella, Jiménez-Sánchez Alfonso, Guzmán Elena C

Abstract excerpt

The observed lengthening of the C period in the presence of a defective ribonucleoside diphosphate reductase has been assumed to be due solely to the low deoxyribonucleotide supply in the nrdA101 mutant strain. We show here that the nrdA101 mutation induces DNA double-strand breaks at the permissive temperature in a recB-deficient background, suggesting an increase in the number of stalled replication forks that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colony Count, Microbial
Share to Deoxyribonucleotides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to DNA Replication

Share to Escherichia coli Proteins

Share to Exodeoxyribonuclease V

Share to Microbial Viability

Share to Ribonucleoside Diphosphate Reductase

Source

Open in PubMed Open full text

Identifiers

PMID: 17322311
DOI: 10.1128/JB.01632-06
PMCID: PMC1855873

Genes

NDP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective ribonucleoside diphosphate reductase impairs replication fork progression in Escherichia coli.PMID 17322311Read ↗

Overlap of replication rounds disturbs the progression of replicating forks in a ribonucleotide reductase mutant of Escherichia coli.Semantic proximity Read ↗

The DNA repair helicase UvrD is essential for replication fork reversal in replication mutants.Semantic proximity Read ↗

Tuning the replication fork progression by the initiation frequency.Semantic proximity Read ↗

Differences in the degree of inhibition of NDP reductase by chemical inactivation and by the thermosensitive mutation nrdA101 in Escherichia coli suggest an effect on chromosome segregation.Semantic proximity Read ↗

Cells defective for replication restart undergo replication fork reversal.Semantic proximity Read ↗

Replication fork reversal after replication-transcription collision.Semantic proximity Read ↗

Replication fork reversal in DNA polymerase III mutants of Escherichia coli: a role for the beta clamp.Semantic proximity Read ↗

Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD.Semantic proximity Read ↗

Stalled replication fork repair and misrepair during thymineless death in Escherichia coli.Semantic proximity Read ↗

sbcB sbcC null mutations allow RecF-mediated repair of arrested replication forks in rep recBC mutants.Semantic proximity Read ↗

Functions of multiple exonucleases are essential for cell viability, DNA repair and homologous recombination in recD mutants of Escherichia coli.Semantic proximity Read ↗

RecBCD enzyme overproduction impairs DNA repair and homologous recombination in Escherichia coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.