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Article

AID protein expression in chronic lymphocytic leukemia/small lymphocytic lymphoma is associated with poor prognosis and complex genetic alterations.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2010

Leuenberger Mona, Frigerio Simona, Wild Peter J, Noetzli Franziska, Korol Dimitri, Zimmermann Dieter R, Gengler Carole, Probst-Hensch Nicole M, Moch Holger, Tinguely Marianne

Abstract excerpt

The biological behavior of chronic lymphocytic leukemia and small lymphocytic lymphoma is unpredictable. Nonetheless, non-mutated IgV(H) gene rearrangement, ATM (11q22-23) and p53 (17p13) deletion are recognized as unfavorable prognosticators in chronic lymphocytic leukemia. The mRNA expression of activation-induced cytidine deaminase (AID), an enzyme indispensable for somatic hypermutation processes, was claimed...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Genes, Immunoglobulin

Share to Immunoglobulin Heavy Chains

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

Identifiers

PMID: 19898425
DOI: 10.1038/modpathol.2009.156

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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AID protein expression in chronic lymphocytic leukemia/small lymphocytic lymphoma is associated with poor prognosis and complex genetic alterations.PMID 19898425Read ↗

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IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions.Semantic proximity Read ↗

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High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia.Semantic proximity Read ↗

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Activation-induced Cytidine Deaminase in B Cell Immunity and CancersSemantic proximity Read ↗

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