Article
IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions.
Blood - 6 Dec 2012
Patten Piers E M, Chu Charles C, Albesiano Emilia, Damle Rajendra N, Yan Xiao-Jie, Kim Dorothy, Zhang Lu, Magli Amanda R, Barrientos Jacqueline, Kolitz Jonathan E, Allen Steven L, Rai Kanti R, Roa Sergio, Mongini Patricia K, MacCarthy Thomas, Scharff Matthew D, Chiorazzi Nicholas
Abstract excerpt
Clonal evolution occurs during the course of chronic lymphocytic leukemia (CLL) and activation-induced deaminase (AID) could influence this process. However, this possibility has been questioned in CLL because the number of circulating AID mRNA(+) cells is exceedingly low; synthesis of AID protein by blood CLL cells has not been demonstrated; the full range of AID functions is lacking in unmutated CLL (U-CLL),...
Topics
- Base Sequence
- Cell Division
- Cells, Cultured
- Cytidine Deaminase
- DNA Breaks, Double-Stranded
- Flow Cytometry
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Leukemic