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Article

AID induces intraclonal diversity and genomic damage in CD86+ chronic lymphocytic leukemia cells

1 Sept 2014

Abstract excerpt

The activation-induced cytidine deaminase (AID) mediates somatic hypermutation and class switch recombination of the Ig genes by directly deaminating cytosines to uracils. As AID causes a substantial amount of off-target mutations, its activity has been associated with lymphomagenesis and clonal evolution of B-cell malignancies. Although it has been shown that AID is expressed in B-cell chronic lymphocytic...

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PMID: 25179679
DOI: 10.1002/eji.201344421

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