Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia

27 Jun 2018

Abstract excerpt

platelets had a shorter life span than control platelets, and macrophage depletion, but not splenectomy, increased platelet counts in mutant mice to control levels. Whole-sternum 3-dimensional confocal imaging and intravital 2-photon microscopy revealed altered morphology of ADAP-deficient MKs with signs of fragmentation and ectopic release of (pro)platelet-like particles into the BM compartment. In addition,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood properties and coagulation
Share to Platelet Disorders and Treatments
Share to Renal Diseases and Glomerulopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29950291
DOI: 10.1182/blood-2018-01-829259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopeniaPMID 29950291Read ↗

Novel insights into mouse models of ectopic proplatelet releaseSemantic proximity Read ↗

Understanding megakaryocyte phenotypes and the impact on platelet biogenesis.Semantic proximity Read ↗

The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functionsSemantic proximity Read ↗

A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesisSemantic proximity Read ↗

Molecular mechanisms of megakaryopoiesisSemantic proximity Read ↗

An age-specific platelet differentiation path from hematopoietic stem cells contributes to exacerbated thrombosisSemantic proximity Read ↗

The genomic and proteomic blueprint of mouse megakaryocytes derived from embryonic stem cells.Semantic proximity Read ↗

Megakaryocyte NLRP3 hyperactivation induces anemia and potentiates inflammatory response in miceSemantic proximity Read ↗

PlateletsSemantic proximity Read ↗

Single-cell analysis of ploidy and the transcriptome reveals functional and spatial divergency in murine megakaryopoiesisSemantic proximity Read ↗

Defining and Harnessing the Megakaryocyte/Platelet CheckpointSemantic proximity Read ↗

Membrane budding is a major mechanism of in vivo platelet biogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.