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Article

Genetic heterogeneity of the NS3 protease gene in hepatitis C virus genotype 1 from untreated infected patients.

Journal of medical virology - 1 Apr 2005

Vallet Sophie, Gouriou Stephanie, Nousbaum Jean-Baptiste, Legrand-Quillien Marie-Christine, Goudeau Alain, Picard Bertrand

Abstract excerpt

NS3 protease is essential for hepatitis C Virus (HCV) replication, and is one of the most promising targets for specific anti-HCV therapy. Its natural polymorphism has not been studied at the quasispecies level. In the present work, the genetic heterogeneity of the NS3 protease gene was analyzed in 17 HCV genotype 1 (5 subtypes 1a and 12 subtypes 1b) samples collected from infected patients before anti-viral...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15714495
DOI: 10.1002/jmv.20302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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