Sequence variation in the gene encoding the nonstructural 3 protein of hepatitis C virus: evidence for immune selection.

doi:10.1007/s00239-001-0037-6

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Sequence variation in the gene encoding the nonstructural 3 protein of hepatitis C virus: evidence for immune selection.

Journal of molecular evolution - 1 Apr 2002

Wang Huiru, Bian Tonghua, Merrill Stephen J, Eckels David D

Abstract excerpt

To determine whether the persistent nature of hepatitis C infection is related to the emergence of antigenic variants driven by immune selection, we examined the sequence heterogeneity in a portion of the hepatitis C virus (HCV) nonstructural 3 (NS3) gene of a patient infected over the course of more than 2 years. By PCR amplification, cloning, and sequencing, we observed several variable and conserved regions in...

Topics

Amino Acid Sequence
Amino Acid Substitution
Cytokines
Epitopes
Genetic Variation
Hepacivirus
Molecular Sequence Data
Mutation
Phylogeny
RNA Helicases
Sequence Analysis, DNA
Viral Nonstructural Proteins

Source

Open in PubMed

Identifiers

PMID: 11956685
DOI: 10.1007/s00239-001-0037-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics