Article
Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays.
Science (New York, N.Y.) - 1 Jan 2010
Drmanac Radoje, Sparks Andrew B, Callow Matthew J, Halpern Aaron L, Burns Norman L, Kermani Bahram G, Carnevali Paolo, Nazarenko Igor, Nilsen Geoffrey B, Yeung George, Dahl Fredrik, Fernandez Andres, Staker Bryan, Pant Krishna P, Baccash Jonathan, Borcherding Adam P, Brownley Anushka, Cedeno Ryan, Chen Linsu, Chernikoff Dan, Cheung Alex, Chirita Razvan, Curson Benjamin, Ebert Jessica C, Hacker Coleen R, Hartlage Robert, Hauser Brian, Huang Steve, Jiang Yuan, Karpinchyk Vitali, Koenig Mark, Kong Calvin, Landers Tom, Le Catherine, Liu Jia, McBride Celeste E, Morenzoni Matt, Morey Robert E, Mutch Karl, Perazich Helena, Perry Kimberly, Peters Brock A, Peterson Joe, Pethiyagoda Charit L, Pothuraju Kaliprasad, Richter Claudia, Rosenbaum Abraham M, Roy Shaunak, Shafto Jay, Sharanhovich Uladzislau, Shannon Karen W, Sheppy Conrad G, Sun Michel, Thakuria Joseph V, Tran Anne, Vu Dylan, Zaranek Alexander Wait, Wu Xiaodi, Drmanac Snezana, Oliphant Arnold R, Banyai William C, Martin Bruce, Ballinger Dennis G, Church George M, Reid Clifford A
Abstract excerpt
Genome sequencing of large numbers of individuals promises to advance the understanding, treatment, and prevention of human diseases, among other applications. We describe a genome sequencing platform that achieves efficient imaging and low reagent consumption with combinatorial probe anchor ligation chemistry to independently assay each base from patterned nanoarrays of self-assembling DNA nanoballs. We...
Read the complete abstract on PubMed