Article
Evolution of genomic sequence inhomogeneity at mid-range scales.
BMC genomics - 5 Nov 2009
Prakash Ashwin, Shepard Samuel S, He Jie, Hart Benjamin, Chen Miao, Amarachintha Surya P, Mileyeva-Biebesheimer Olga, Bechtel Jason, Fedorov Alexei
Abstract excerpt
BACKGROUND: Mid-range inhomogeneity or MRI is the significant enrichment of particular nucleotides in genomic sequences extending from 30 up to several thousands of nucleotides. The best-known manifestation of MRI is CpG islands representing CG-rich regions. Recently it was demonstrated that MRI could be observed not only for G+C content but also for all other nucleotide pairings (e.g. A+G and G+T) as well as for...
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