Large scale variation in the rate of germ-line de novo mutation, base composition, divergence and diversity in humans.

Abstract excerpt

It has long been suspected that the rate of mutation varies across the human genome at a large scale based on the divergence between humans and other species. However, it is now possible to directly investigate this question using the large number of de novo mutations (DNMs) that have been discovered in humans through the sequencing of trios. We investigate a number of questions pertaining to the distribution of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Base Composition
• Share to Datasets as Topic
• Share to Gene Conversion