Article
Genome-wide linkage scan of a large family with IgA nephropathy localizes a novel susceptibility locus to chromosome 2q36.
Journal of the American Society of Nephrology : JASN - 1 Aug 2007
Paterson Andrew D, Liu Xiao-Qing, Wang Kairong, Magistroni Riccardo, Song Xuewen, Kappel Joanne, Klassen Judith, Cattran Daniel, St George-Hyslop Peter, Pei York
Abstract excerpt
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and an important cause of ESRD. Familial clustering of cases suggests genetic predisposition to this disease. Two recent genome-wide studies in IgAN have identified a major susceptibility locus on chromosome 6q22 (IGAN1) and two additional loci with suggestive linkage signals on chromosomes 4q26-31 and 17q12-22. A large four-generation family...
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