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Article

Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2010

Engel Tobias, Murphy Brona M, Hatazaki Seiji, Jimenez-Mateos Eva M, Concannon Caoimhin G, Woods Ina, Prehn Jochen H M, Henshall David C

Abstract excerpt

The functional significance of neuronal death for pathogenesis of epilepsy and the underlying molecular mechanisms thereof remain incompletely understood. The p53 transcription factor has been implicated in seizure damage, but its target genes and the influence of cell death under its control on epilepsy development are unknown. In the present study, we report that status epilepticus (SE) triggered by...

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Identifiers

PMID: 19890018
DOI: 10.1096/fj.09-145870
PMCID: PMC3231945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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