Article
Suppression of the intrinsic apoptosis pathway by synaptic activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Feb 2010
Léveillé Frédéric, Papadia Sofia, Fricker Michael, Bell Karen F S, Soriano Francesc X, Martel Marc-André, Puddifoot Clare, Habel Marlen, Wyllie David J, Ikonomidou Chrysanthy, Tolkovsky Aviva M, Hardingham Giles E
Abstract excerpt
Synaptic activity promotes resistance to diverse apoptotic insults, the mechanism behind which is incompletely understood. We show here that a coordinated downregulation of core components of the intrinsic apoptosis pathway by neuronal activity forms a key part of the underlying mechanism. Activity-dependent protection against apoptotic insults is associated with inhibition of cytochrome c release in most but not...
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