Article
Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Apr 2006
Kochanek Patrick M, Vagni Vincent A, Janesko Keri L, Washington Christopher B, Crumrine Patricia K, Garman Robert H, Jenkins Larry W, Clark Robert S B, Homanics Gregg E, Dixon C Edward, Schnermann Jurgen, Jackson Edwin K
Abstract excerpt
Adenosine, acting at A1 receptors, exhibits anticonvulsant effects in experimental epilepsy--and inhibits progression to status epilepticus (SE). Seizures after traumatic brain injury (TBI) may contribute to pathophysiology. Thus, we hypothesized that endogenous adenosine, acting via A1 receptors, mediates antiepileptic benefit after experimental TBI. We subjected A1-receptor knockout (ko) mice, heterozygotes,...
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