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Article

Functional genomic screens identify CINP as a genome maintenance protein

4 Nov 2009

Abstract excerpt

The DNA damage response (DDR) has a critical role in maintaining genome integrity and serves as a barrier to tumorigenesis by promoting cell-cycle arrest, DNA repair, and apoptosis. The DDR is activated not only by genotoxic agents that induce DNA damage, but also during aberrant cell-division cycles caused by activated oncogenes and inactivated tumor suppressors. Here we use RNAi and cDNA overexpression screens...

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PMID: 19889979
DOI: 10.1073/pnas.0909345106

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