Article
Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis.
Genesis (New York, N.Y. : 2000) - 1 Jan 2008
Izvolsky Konstantin I, Lu Jining, Martin Greg, Albrecht Kenneth H, Cardoso Wellington V
Abstract excerpt
Heparan sulfate (HS) proteoglycans modulate the biological activity of a number of growth factors in development, homeostasis, and cancer. Specific modifications of HS chains by HS biosynthetic enzymes have been implicated in growth factor signaling in multiple aspects of organogenesis. Although the role of HS 6-O-sulfotransferases has been described in processes such as trachea formation in Drosophila and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.