Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit.

The Journal of biological chemistry - 30 Aug 1996

Braun J R, Willnow T E, Ishibashi S, Ashwell G, Herz J

Abstract excerpt

The mammalian asialoglycoprotein receptor (ASGPR) is located on the sinusoidal membrane of hepatocytes where it binds and endocytoses galactose-terminated glycoproteins (asialoglycoproteins). ASGPR is composed of two highly homologous subunits, termed hepatic lectin 1 and 2. Despite numerous studies the contribution of both subunits to biosynthesis and functional activity of ASGPR in vivo has remained...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Membrane
Share to Lectins
Share to Liver

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Phenotype

Share to Receptors, Cell Surface

Source

Identifiers

PMID: 8702886
DOI: 10.1074/jbc.271.35.21160

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit.PMID 8702886Read ↗

Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit.Semantic proximity Read ↗

Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit. Its obligate requirement for the stable expression of oligomeric receptor.Semantic proximity Read ↗

The Ashwell-Morell receptor.Semantic proximity Read ↗

Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins.Semantic proximity Read ↗

Normal levels of serum glycoproteins maintained in beta-1, 4-galactosyltransferase I-knockout mice.Semantic proximity Read ↗

ASGR1 deficiency improves atherosclerosis but alters liver metabolism in ApoE-/- mice.Semantic proximity Read ↗

Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice.Semantic proximity Read ↗

Closely related mammals have distinct asialoglycoprotein receptor carbohydrate specificities.Semantic proximity Read ↗

Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance.Semantic proximity Read ↗

Asialoglycoprotein receptor subunit Asgr1a loss results in attenuated cholesterol absorption in zebrafish fed a western diet.Semantic proximity Read ↗

Enhanced expression of the mannose receptor by endothelial cells of the liver and spleen microvascular beds in the macrophage-deficient PU.1 null mouse.Semantic proximity Read ↗

A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.