Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease.

doi:10.1186/s40478-021-01140-7

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Article

Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease.

Acta neuropathologica communications - 16 Mar 2021

Monti Giulia, Kjolby Mads, Jensen Anne Mette G, Allen Mariet, Reiche Juliane, Møller Peter L, Comaposada-Baró Raquel, Zolkowski Bartlomiej E, Vieira Cármen, Jørgensen Margarita Melnikova, Holm Ida E, Valdmanis Paul N, Wellner Niels, Vægter Christian B, Lincoln Sarah J, Nykjær Anders, Ertekin-Taner Nilüfer, Young Jessica E, Nyegaard Mette, Andersen Olav M

Abstract excerpt

SORL1 is strongly associated with both sporadic and familial forms of Alzheimer's disease (AD), but a lack of information about alternatively spliced transcripts currently limits our understanding of the role of SORL1 in AD. Here, we describe a SORL1 transcript (SORL1-38b) characterized by inclusion of a novel exon (E38b) that encodes a truncated protein. We identified E38b-containing transcripts in several brain...

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Identifiers

PMID: 33726851
DOI: 10.1186/s40478-021-01140-7
PMCID: PMC7962264

Genes

SORL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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