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Article

Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Nov 2009

Dubreuil Véronique, Thoby-Brisson Muriel, Rallu Murielle, Persson Karin, Pattyn Alexandre, Birchmeier Carmen, Brunet Jean-François, Fortin Gilles, Goridis Christo

Abstract excerpt

The retrotrapezoid nucleus (RTN) is a group of neurons in the rostral medulla, defined here as Phox2b-, Vglut2-, neurokinin1 receptor-, and Atoh1-expressing cells in the parafacial region, which have been proposed to function both as generators of respiratory rhythm and as central respiratory chemoreceptors. The present study was undertaken to assess these two putative functions using genetic tools. We generated...

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Identifiers

PMID: 19940179
DOI: 10.1523/JNEUROSCI.2623-09.2009
PMCID: PMC6665996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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