Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans

Abstract excerpt

Anterolateral system neurons relay pain, itch, and temperature information from the spinal cord to pain-related brain regions, but the differentiation of these neurons and their specific contribution to pain perception remain poorly defined. Here, we show that most mouse spinal neurons that embryonically express the autonomic-system-associated Paired-like homeobox 2A (Phox2a) transcription factor innervate...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Axon Guidance and Neuronal Signaling
• Share to Neuropeptides and Animal Physiology
• Share to Pain Mechanisms and Treatments